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KMID : 0351819980390010061
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Kyunpook University Medical Journal
1998 Volume.39 No. 1 p.61 ~ p.71
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IS EVENT-RELATED POTENTIAL CHANGE DUE TO COGNITIVE DYSFUNCTION IN PARKINSON´S DISEASE
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Kim Jong-Yeol
Kim Jung-Il
Park Sung-Pa
Suh Chung-Kyu
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Abstract
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Objective: P3 has been utilized as an objective electrophysiologic index of cognitive function in dementia and other diseases. P3 latency is ]mown to be del;iyed in Parkinson´s disease(PD) with both dementia and nondementia. As PD progresses, the motor an~i cognitive functions decline. To find out whether P3 changes in PD is due to cognitive dysfunction or not, we investigate the relationship between the P3, cognitive impairment, and other clinical parameters. We also studied the change of P3 and cognitive dysfunction in PD, and their relationship as the disease progressed in patients.
Materials and Methods: 30 PD(mean age, 64.2 years) patients and 43 control(mean, 53.9 years) subjects were examined with auditory oddball paradigm to elicit event-related potentials(ERPs). Neurological variables such as disease duration, Hcehn and Yaltr stage, mini mental state examination of Korean version score(MMSE-K), medication, and Unified Parkinson Disease Rating Scale(UPDRS) subclass 1, II, and III were also analyzed in PD. A follow up study with some patients was performed(mean, 30 months).
Results: There were no significant differences in latency of the ERP between PD patients as a whole and controls but significant differences in PD with dementia(M[MSE-K < 26) and controls. In PD, ERPs were prolonged in demented patients compared with that of nondemented group. Latency of P3 correlated with UPDRS I score and inversely with MMSE-K score but did not have direct relationship with. disease duration, Hcehn and Yahr stage, UPDRS II and [II scores and dosage of medication. We did not find any significant changes of P3 between the initial and follow-up studies in PD patients whose MMSE-K score did not change significantly.
Conclusion: Our study revealed that P3 changes in PD patients were due to cognitive dysfunction but not to disease duration, or motor dysfunction.
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KEYWORD
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P3, Event related potential, Parkinson´s disease
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